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Other studies indicate that lower serum IGF-1 concentrations are associated with reduced cognitive function, showing a negative correlation with age, disease duration, and modified Rankin Scale [134, 135], yet a positive association with more substantial declines in Minimum Mental State Examination (MMSE) scores, CSF A 1-42 /A 1-40 ratio, and diminishing recall, language fluency, attention, and numeracy function [134, 136]

When the kidneys are damaged, they produce less erythropoietin (EPO), which is a hormone that tells your bone marrow to produce red blood cells

Cellular redox signaling, influenced by fluctuations in ROS, RNS, and antioxidant systems, governs vital functions like cell growth, programmed death, and immune responses [112]

Moreover, recent clinical studies have shown that HCM-causative FHOD3 mutations increase the risk of cardiovascular death and all-cause death, with the onset of the disease occurring as early as age 4 and as late as age 63 (Vodnjov et al., 2023