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J Neuropathol Exp Neurol 2011;70:979-91

Longitudinal tumour growth was assessed using a joint modelling approach from the Jmbayes2 package (version 0.3-1), which incorporates survival data and mixed linear modelling for longitudinal tumour growth to account for missing not at random (MNAR) data at timepoints where animals have been removed from the study due to ethical endpoints related to maximum tumour size

However, substituting the ethyl ester with an amide group, as in SRS9-11 (EC50 = 950 nM), resulted in a notable reduction in activity, though this finding was later contradicted by Hofmans et al