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ALK5 knockdown and its downstream pathway protected LUHMES cells from aSyn-induced toxicity To verify that the knockdown of ALK5 protected against aSyn-induced toxicity, we first validated whether the siPOOL siRNA against ALK5 could effectively and specifically reduce ALK5 mRNA expression

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In particular, we hereby propose the putative functionally relevant conformational change of the C terminus after the transfer of reducing equivalents from NADPH to the redox sites of the enzyme.