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These include issues like Addisons disease or Cushings syndrome, and sometimes lip darkening is one of the first signs

Signs of Vitamin B12 Deficiency Some common signs that you may be deficient in Vitamin B12 include fatigue or tiredness, weakness, difficulty concentrating or thinking clearly, pale skin, dizziness or light-headedness, loss of appetite, weight loss, constipation or diarrhea, numbness or tingling in the hands and feet, sore tongue, headaches and vision problems

This regulation can lead to decreased food cravings and better appetite control, making it easier for patients to maintain their dietary goals

Binding is through the heme iron to two histidine residues of hemopexin ( 149 , 150 , 151 , 152 )