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PMID: 33181153 6 Clinical features and genotyping of patients with primary carnitine deficiency identified by newborn screening

Tumor cells heavily rely on Gln to counteract oxidative stress, yet recent studies demonstrate that glutamine deprivation or treatment with the glutamine analog DON induces epigenetic remodeling via trimethylation of histone H3K4me3, selectively upregulating HMOX1 transcription while inhibiting the activity of system Xc- subunit SLC7A11 and GPX4, thereby promoting lipid peroxidation-derived ROS accumulation and ultimately triggering ferroptotic cell death [63]

FMR1 CGG allele size and prevalence ascertained through newborn screening in the United States