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The role of mtROS in host-pathogen interactions extends to Pseudomonas aeruginosa , where quorum-sensing molecules induce mitochondrial depolarization and oxidative stress, contributing to tissue injury in chronic lung infections ( 3.5 Bacteria-induced mtDNA release and activation of innate immune Mitochondrial damage induced by bacterial effectors often results in mtDNA leakage into the cytosol or extracellular environment

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160 In addition, Wnt2b and TCF7L2, encoding an important transcription factor TCF4, are associated with the susceptibility of T2D among individuals with impaired glucose tolerance 161 (Fig