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ALDH then converts the latter into acetic acid, which is broken down into water and CO2 before being eliminated via respiration

doi: 10.1016/j.mce.2009.07.031 364 Al-SulaitiHDmlingAElrayessMA

This leads to impaired bacterial clearance and contributes to the immunosuppressive state of sepsis, while mice lacking IRAK3 exhibited improved host defense and survival (Deng et al., 2006)