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In a retrospective study, it was observed that subjects receiving doses of metformin higher than 2000 mg/day or for more than 4 years had low levels of vitamin B 12 [18]

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van de Rest O, van Hooijdonk LW, Doets E, et al

These SCP mechanisms include both the use of Locational Marginal Pricing (LMP) in short-run (day-ahead, intra-day) markets and the use of highest clearing supply price (possibly inflated by a subjective multiplier) in longer-run capacity markets with administratively set demand curves