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63 The accumulated NAPQI depletes GSH in the endoplasmic reticulum to induce an oxidationreduction imbalance, which initiates the phosphorylation of eukaryotic initiation factor 2 (eIF2) to activate ATF6 and CHOP, eventually resulting in hepatocyte apoptosis (Figure 2)

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Nearly 190 years of medical use, billions of treatments worldwide, and strict FDA, CDC, and professional oversight all point to the same conclusion: IV therapy is safe when proper medical protocols are followed

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