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iv) Hypoxia: The tumors aberrant vasculature and high oxygen demand result in hypoxia, and reduced availability of nutrients like glucose and vital amino acids [266, 267]

Generation of Enteroid Monolayers Duodenal biopsies were obtained from five healthy individuals, two pediatrics (ages 2 and 5 years) and three adults (ages 25, 27, and 81 years) through endoscopy or surgical procedure

Ultimately, this conceptual framework posits that dietary patterns modulate the gut microbiota, which in turn functions as a dynamic bioreactor via microbial metabolism to produce signaling molecules that manifest as serum metabolites