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Mechanisms of oxidative stress in aging Functional changes induced by aging Human aging is a complex physiological process characterized by the gradual deterioration, damage, and even loss of tissue and organ functions over time

Anal Biochem 167:284289 Weber K, Osborn M (1969) The reliability of molecular weight determinations by dodecyl sulfate polyacrylamide gel electrophoresis

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The lack of adequate cobalamin in the body hinders the regeneration of tetrahydrofolate, which eventually leads to megaloblastic anemia due to the functional folate deficiency.[9][10] On the other hand, the methylmalonyl-CoA mutase helps to metabolize odd chain fatty acids and branch chain amino acids.[5] Cobalamin is also thought to keep the bodys level of sulfhydryl (SH) groups in reduced form