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Saleh et al., 2019) to examine age differences in GSH levels in the frontal and sensorimotor cortices, brain regions involved in cognitive function and mobility, respectively

This phenomenon is attributed to the expression of key enzymes of the glycolytic pathway (hexokinase, fructose-6-phosphate activating enzyme, and pyruvate kinase), which are not normally present in the proximal tubules (Guder and Ross, 1994

Updated 12/6/2023

[PubMed: 32212340] (Among 20 adults with multiple sclerosis given either 600 mg of an R enantiomer of ALA or 1200 mg of a racemic mixture of the R and S enantiomers for 7 days and then crossed over to the other dosage, absorption and ALA[R] plasma concentration areas under the curve were similar for the 2 forms but gastrointestinal side effects were greater with the 1200 mg dosage