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In a phenylketonuria mouse model, dual AAV-mediated delivery of an intein-split Staphylococcus aureus KKH-CBE3 achieved approximately 23% on-target correction of the disease-causing Pahenu2 mutation, reversing the disease phenotype without detectable transcriptome-wide or genome-wide off-target mutations [246, 247]

In line with physical activity improvements, muscle mass declines during aging, leading to sarcopenia, and it is well established that resistance training counteracts sarcopenia 20 , but resistance training combined with collagen peptide supplementation showed further improvements in increasing lean body mass (i.e., muscles) in young and old sarcopenic men 21,22,23,24,25 , decreased fat mass and increased lean mass and hand-grip strength in pre-menopausal women in double-blinded randomized clinical trials 15

Large-scale, long-term randomized trials have been conducted, and are ongoing, to evaluate the viability of dulaglutide as a therapeutic agent for the treatment of T2DM (63)

Nitric oxide mitigates salt stress by regulating levels of osmolytes and antioxidant enzymes in chickpea