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In particular, increased Gram-negative bacteria expose KCs to an elevated amount of LPS and upregulation of PRRs ( Also, the association between obstructive sleep apnea syndrome (OSAS) and NASH severity seems to correlate with endotoxemia increase and gut barrier function alteration, conducing to increased hepatic susceptibility to endotoxemia mediated by TLR-4 (98)

Employing this rat model of HMG-induced lung injury, we observed significant attenuation of the pulmonary injury when experimental animals were complement or neutrophil depleted prior to HMG challenge

folic acid alone could not influence the migraine symptoms in these patients (72)

Brodzki et al