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Interestingly, direct intrinsic hepatotoxicity was detected in 2D cultured HepaRG cells, which was, however, slightly increased in 3D liver models at the highest concentration of TVX

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AOP-helpFinder assigned a very high Cs to this relationship, identifying over 700 relevant abstracts (KER 1, Table 1)

It accomplishes this through a complex cascade of biological pathways, including the promotion of angiogenesis (the formation of new blood vessels), modulation of nitric oxide, and interaction with growth factors