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Kells AP, Eberling J, Su X, et al

10.1038/s41598-023-33130-1 20 CiullaL.MoorthyM.MathewS.SieskyB.Verticchio VercellinA

Only 2 His-specific methyltransferases have been identified: METTL18, which methylates the nitrogen in position 3 of histidine imidazole ring (generating 3-methylhistidine, 3MH) mainly in RPL3 protein, modulating translational elongation 12,13 and METTL9, which was found to methylate the nitrogen 1 of histidines (generating 1MH) in hundreds of proteins containing the H[ANGST]H motif 14