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54% of patients were also found to exhibit depressive symptoms in a study of the prevalence of psychiatric comorbidities in subjects with mitochondrial cytopathies (Feng et al., 2020), suggesting that targeting mechanisms of mitochondrial dysfunction may be a possibility for developing new treatments for depression

For such prospective melanogenesis inhibitors, further in vitro/in vivo studies and clinical trials are required to evaluate efficacy and safety

Furthermore, selective inactivation of Fto in the hypothalamus, a key site for the nutritional regulation of Fto expression, results in reduced food intake and body weight gain

An unhealthy gut can heighten inflammation and insulin resistance, crucial factors in diabetes onset and progression