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We previously discovered that, regardless of its activation state, D2R can enhance the membrane expression of DAT and consequently DAT-mediated reuptake of dopamine through their direct protein-protein interaction [23]

The titration ramp for cagrilintide takes 16 weeks even at the conservative cadence, which extends the side-effect runway

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Then, the rats started to drink excessively, then to eat and repeatedly drink water for a period of a few minutes after which they regained normal behavior, drank and then ate and showed no behavioral abnormalities until their sacrifice ( Table 6 )