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Even with this low level of oxygen, the lens normally derives a proportion of its ATP from oxidative phosphorylation, a process that, of necessity, generates free radicals

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5.1.1.3 Glutathione peroxidase (GPx) The GPx, abundantly found in the cytosol and mitochondria, protects live cells against ROS through minimising lipid peroxidation

it can be enzymatically detoxified or it reacts with proteins, transition metals or carbon dioxide ( 2 O 2 can be removed by the action of glutathione peroxidase (GPx), catalase (CAT), or peroxiredoxin, all of which convert it to water and oxygen ( 2 O 2 encounters a transition metal such as divalent iron (Fe 2+ ), it is non-enzymatically converted to the highly reactive hydroxyl radical (OH)