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Since an intramolecular disulfide bond forms between the N- and C-terminal CRDs (Cys310-Cys629 and Cys303-Cys598), the higher amounts of reactive oxygen species cause Yap1 to undergo transitory redox-induced conformational changes that hide the NES

Redox Biol 37:101674 Ovalle F, Grimes T, Xu G, Patel AJ, Grayson TB, Thielen LA, Li P, Shalev A (2018) Verapamil and beta cell function in adults with recent-onset type 1 diabetes

Other authors have found that angiotensin II significantly stimulates peroxide formation in monocytes

Factors That Affect How Long B12 Stays in the Body Several factors influence how long B12 stays in the body, including health conditions, metabolism, and age