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This study also importantly demonstrates that metformin treatment significantly alters the metabolic profile and inflammatory secretome in rectal cancer biopsies, with minimal impact on non-cancer rectal tissue, supporting its potential as a radiosensitising agent in rectal cancer

In this study, the dosage of B vitamins and vitamin C was 3 to 12 times the current US RDA, zinc was contained at an amount almost the RDA, and the supplement also contained fractions of the RDA for calcium and magnesium (138)

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