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[95] NF-B is activated in a variety of cell types that undergo normal or accelerated aging

Within that group, diet is one of the most important in its effect on barrier function

It can therefore be suggested that an attenuated gut barrier, as a result of genetic and environmental factors, is likely to aid the spread of novel proteins/peptides generated by intestinal PAD and tTG thereby promoting disease development, or at least exacerbation of symptoms (Lerner and Matthias 2015b)