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All measurements of gold standards solution and samples were carried out with ICP-MS system using Rhenium as internal standard (20 parts per billion, ppb) (ICAP Q, Thermo)

ABC transporters play a crucial part in cancer drug resistance, as they can increase the cellular efflux of anticancer drugs 65

B12 also plays a role in cell replication and helps regulate foetal growth

This is in agreement with previous observations that electron tunneling between redox centers separated by distances below 14 occur at rates fast enough not to be a limiting factor for substrate turnover 15