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In vitro, astrocyte-to-microglia transfer of protein aggregates improved clearance [147]

In contrast, though pig pancreatic extract is one of the widely used sources of pancreatic lipase, and has been shown to be quite similar to the human pancreatic extract, the porcine pancreatic extract esterase hydrolyzes triglycerides and other digestible LbDDS excipients to free FAs [102]

Extensive clinical and experimental evidence supports the involvement of glutamate-induced excitotoxicity in the onset and progression of PD (Figure 3D) (Ribeiro et al., 2017