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Morphologically, it is mainly manifested as ultrastructural changes of mitochondria, such as shrinkage of mitochondria, increased density of mitochondrial membrane, and rupture of mitochondrial cristae and outer membrane

Chronic but not intermittent infection with pseudomonas aeruginosa is associated with global changes of the lung microbiome in cystic fibrosis

For decades, the dominant clinical paradigm treated low testosterone as a symptomatic complaint to be addressed with straightforward replacement, the same way a physician might replace a deficient thyroid hormone

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