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Moreover, researchers have also confirmed that GTP cyclohydrase 1 (GCH1) inhibits the production of PLOOH through its metabolite BH2/4

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10.1111/psyp.13796 Summary Keywords arterial spin labelling, cerebral autoregulation, cerebral perfusion, cerebrovascular reactivity, functional magnetic resonance imaging, hypercapnic challenge, neurovascular coupling, transcranial doppler Citation Khartabil Z, Kala D, Prysiazhniuk Y and Othal J (2026) Neurovascular coupling and cerebrovascular reactivity: physiology, lifespan development, pathophysiology, and clinical relevance

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