mitochondrial glutathione transporter Autoregulatory control of homeostasis Mitochondria: Biogenesis, Functions, and Disease

Estrogen Metabolism Support Optimizing hepatic Phase I and Phase II estrogen detoxification reduces the burden of potentially carcinogenic estrogen metabolites (particularly 4-OH and 16-OH estrone) and may reduce estrogen-driven fibroid growth: DIM (diindolylmethane): Shifts estrogen metabolism toward the favourable 2-OH pathway Calcium-D-glucarate: Inhibits -glucuronidase, preventing deconjugation and reabsorption of estrogens in the gut (Note: off-the-shelf detox kits from health food stores are not equivalent to therapeutic doses of these specific compounds) N-acetylcysteine (NAC): Supports glutathione synthesis and Phase II sulphation 3

These treatments are generally safe but its important to speak with your provider before starting any new supplements, especially if you take other medications

10.3390/antiox12051126 Antioxidants 69 MuhialdinB

& Settleman, J