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After incubation with increasing concentrations of UA, the expression of GCL in the macrophage cell line elevated in a concentration-dependent manner

Pathological studies have shown that iNOS-expressing macrophages can be detected in AAV lesions, suggesting that the metabolic reprogramming of arginine toward the NO pathway is closely associated with the activation of pro-inflammatory macrophages (102)

doi:10.1002/ptr.6702

Regulatory Considerations for NAC FDA has concluded that NAC was approved as a drug before it was marketed as a dietary supplement or food and therefore is excluded from the statutory dietary-supplement definition