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Despite the protective role of AhR within HSCs, exposure to potent environmental AhR ligands (such as the dioxin TCDD) is often reported to promote liver fibrosis ( Most current research on AhR in hepatic fibrosis focuses on preventing fibrosis progression

tuberculosis inside the macrophages and also produced increased levels of IL-2, IL-12, and IFN-, essential for the Th1 response and control of intracellular pathogens

In contrast, Gpx1/2 knockout animals are generally healthy in the lab despite being predisposed to ileocolitis during weaning and developing commensal microbiota-dependent ileal and colonic tumors by the age of 6 months (Chu et al., 2004

Labs to calculate FIB-4 scores and baseline demographic and referral data were extracted from the EMR