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Cellular ROS assay

Its downregulation in diabetes leads to impaired mitochondrial Ca 2+ uptake and was found to be associated with a decreased capacity to upregulate ATP synthesis in response to increased workload, resulting in contractile dysfunction ( 2+ handling, while decreasing oxidative stress and cardiomyocyte apoptosis ( 2+ uptake and release, respectively

To assess the general relevance of the investigated positions in the context of alternative arGSTs, we introduced three selected substitutions (A/V12M, C13S and N108H) into the two well-studied arGSTs Ph AN9 and Vv GST4