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Description

In the 1940s, the indirect effects of radiation were correlated with free radical formation, and although it can explain the indirect effects of radiation, the effects of free radicals have proven to be secondary and transient

Neuronal fibrous tangles are created when Tau proteins are phosphorylated abnormally

Materials and methods Animals Locally bred male Albino-Wistar rats (n = 12) utilised in the study, were purchased from Dow University of Health Sciences, OJHA campus, Karachi, Pakistan

Reduced expression of tyrosine hydroxylase and TPH, biochemical markers of neuronal integrity, was observed after mephedrone administration, along with downregulation of dopamine D2 receptors in the striatum, indicating the presence of damaged nerve endings 48,49