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Efficiency of signalling through cytokine receptors depends critically on receptor orientation

So theyre not ideal for initially correcting a deficiency, although theyre sometimes used to maintain vitamin B12 levels

Medical Articles Comparative analysis of the use of autologous exosomes and platelet-derived growth factors in women with premature ovarian insufficiency and infertility: A prospective, randomized, observational, analytical study After completing the study, it was found that women in the Autologous Exosome group showed better ovarian reserve parameters such as FSH, LH, Estradiol, Anti-Mllerian Hormone and antral follicle count, edema of more oocytes collected in Metaphase II, higher fertilization rate, frozen embryos and positive pregnancies

doi: 10.1016/j.mad.2009.10.002