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Manipulation of the gut microbiome through dietary-derived metabolites is an appealing approach in personalised settings, particularly for individuals with specific dietary requirements or medical constraints, such as food allergies, or limited access to certain food

10.1016/j.metabol.2010.03.010 56

However, this method has also a disadvantage such as high production costs of (R)-4-chloro-3-hydroxybutyrate derivate, and a difficulty of application thereof to industrial-scale production in that the reaction must be carried out under high- temperature and high-pressure conditions