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LARS1 lactylation inhibits autophagy by activating mTORC1 to promote podocytes injury in diabetic kidney disease

Metabolomic profiling Samples for metabolomics were quick frozen in liquid N2, stored at -80C, and shipped on dry ice to the UC Davis NIH West Coast Metabolomics Center ( An untargeted analysis of primary metabolites was performed using automatic liner exchange chromatography and cold injection gas chromatography (GC) time of flight (TOF) mass spectrometry methods as detailed in Fiehn et al

Beyond its antioxidant role, Glutathione is central to Phase II hepatic detoxification research, where it acts as a conjugate for electrophilic xenobiotics and reactive metabolites via glutathione S-transferase (GST) enzymes, facilitating their excretion

An instance is trastuzumab as a monoclonal antibody that can bind to HER2 protein expressed on the surface of breast tumor cells, suppressing cancer proliferation [145]