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Ginger extract exhibited the antioxidant effects in IL-1-mediated OS in human C28I2 chondrocyte cells by stimulating the expression of several AOEs, decreasing IL-1-induced ROS production, LPx, and by reducing apoptosis (Bax/Bcl-2 ratio, and caspase-3 activity) (130) ( Supplementary Table 1 )

Third, exposure of N1IC cells to RSL3 led to a significant increase in BODIPY-C11 fluorescence, a marker of increased lipid peroxidation, starting at approximately 10 min after drug treatment (Appendix Fig

Exercise, resveratrol, and statins increase antioxidant defenses and show promise in reducing the risk of age-related AF in preclinical or clinical studies, pending further validation through larger-scale studies

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