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It is highly plausible that such long-term exposures trigger entirely different and more subtle toxicity pathways, such as endocrine disruption, metabolic reprogramming, or even transgenerational epigenetic effects, which are invisible in standard 96 hour acute assays.188,189 Toxicity of the Nano-Waste Stream: in any real application, aquatic ecosystems will be exposed to a complex nano-waste stream comprising a mixture of the original ENMs, their various environmentally transformed progeny, the target pollutants, and the pollutant degradation by-products