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Many peripheral, perhaps all, cells in tissues of both animal and plant eukaryotic organisms produce melatonin likely as a protection against biomolecular destruction by ROS/RNS as well as other functions

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A single layer of epithelial cells form the main physical barrier between the lumen and mucosal tissues

J Chromatog 642:1532 Levsen K, Schiebel H-M, Behnke B, Dotzer R, Dreher W, Elend M, Thiele H (2005) Structure elucidation of phase II metabolites by tandem mass spectrometry: an overview