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In the absence of myelin, redistribution of Na + occurs to maintain the transmission of nerve impulses that increases energy demand, and this produces a situation of virtual hypoxia. At the end, the demand exceeds the capacity of axonal mitochondria to produce enough ATP, which causes an increase in the concentration of Ca 2+ in the axon

Acute respiratory distress syndrome

That multi-pathway design reflects a broader view in aging biology: because aging affects many systems at once, interventions aimed at only one target may have limited effects

Recently, this drug has been approved by the FDA for use as a weight management drug to treat obesity and certain overweight patients who meet the criteria