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Hyperammonaemia triggers numerous neurological and neuropsychiatric symptoms, including poor concentration, impaired memory and cognition, psychotic presentations, sleep disturbance and lethargy, and stupor and coma in severe cases

The strategies for managing fatigue and PEM mainly focus on symptom relief and functional improvement

It is expected that improvement or augmentation of endothelial function will prevent the development of atherosclerosis, resulting in reduction in cardiovascular and cerebrovascular events

The metabolic reprogramming of myeloid immune cells is one of the driving forces shaping the immunosuppressive microenvironment