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Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells

This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access 265,23 per year only 22,10 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

Wheler J, Hong D, Swisher SG , Falchook G, Tsimberidou AM, Helgason T, Naing A, Stephen B, Janku F, Stephens PJ, Yelensky R, Kurzrock R

In contrast, in non-glucose starved cells, with the presence of 10 mM glucose in all perfusion buffers, no NADP oxidation was observed, even with continuous perfusion of buffer containing 20 M H 2 O 2