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Description

While GA-AuNPs show promising selectivity and dual-mode action, their efficacy is highly dependent on tumor vasculature and may be less effective in poorly perfused or hypoxic regions (Table 2)

HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression

Second, the reaction of the GSH thiol group with dopaquinone, leading to the formation of a sulphydryldopa conjugate and finally to a sulfur-containing pigment, pheomelanin instead of eumelanin [8284]