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A 2025 meta-analysis of 7 RCTs (n=456) reported standardized mean differences of -0.72 for wrinkles (95% CI -1.02 to -0.42

The retraction is permanent and the paper should no longer be cited as evidence for the HGF/c-Met mechanism, although the underlying mechanism has been corroborated in subsequent independent work (e.g., Sun et al