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Overall quality of evidence The quality and consistency of each comparison was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines through GRADEpro (Balshem et al

Peer review Peer review information Nature Chemistry thanks the anonymous reviewers for their contribution to the peer review of this work

Gene enrichment analysis showed that E2F Target genes as well as genes that regulate the G2-M checkpoint were significantly downregulated ( Figure 2B top)