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MgIG also downregulates the mRNA expression of TLR2, TLR4, and NF-B in the liver, thereby reducing the production of pro-inflammatory cytokines (e.g., TNF-, IL-6) and alleviating liver tissue inflammation and oxidative stress (Chopyk and Grakoui, 2020

The characteristic hypermethylation within promoter regions of colorectal cancer tumor suppressor genes indicates that the epigenome likely plays a key role in mediating non-genetic sequence modifications driving malignant phenotype (182)

These findings strongly suggest that compounds derived from Heptaptera triquetra, particularly colladin, hold significant promise as natural therapeutic agents for the management of neurodegenerative and ocular diseases [155]

As cheeses and yogurts have shown more enhanced health benefits than regular milk, it has been proposed that fermentation plays a rolehighlighting the need for dietary guidelines to differentiate between fermented and non-fermented dairy products and further exploring the underlying metabolic mechanisms (14)