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doi: 10.1016/j.tins.2021.11.003 196 ReddyC.SainiA

Further, the decrease in GCase activity is also associated with ER stress triggered by the unfolding of mutant GCase and impaired mitophagy [13]

Given that low lactate dehydrogenase levels represent a high mitochondrial metabolic state, this finding is consistent with the observation that cells with high levels of lipoylated TCA enzymes and a hyperactive mitochondrial respiratory rate are more sensitive to elesclomol