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In previous reports, Asp60 hTrx1 has been mentioned as an important residue that quenches Trp31 hTrx1 (refs 17,25)

Those targeting wound healing or broader systemic tissue repair may work up toward 25 mg/day under research supervision

Long-term oral studies of acetylcysteine alone in rats (12 months of treatment followed by 6 months of observation) at doses up to 1,000 mg/kg/day (5.2 times the human mucolytic dose) provided no evidence of oncogenic activity

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