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Animal Model:Hyperreactive rats (male and female, 200-400 g, pretreated intravenously with 3 g/kg methysergide, 5 min before antigen chdlenge) [1] Dosage:0.5, 0.15, and 0.05 mg/kg Administration:Orally, once, 1 or 4 h before challenge Result:Produced dose-dependent inhibition of the duration of antigen-induced dyspnea, with ED 50 values of 0.13 (95% confidence interval (CI), 0.03-0.62) and 0.11 (95% CI, 0.009-1.47) mg/kg, respectively

Unclear long-term safety: There is limited data on chronic use or systemic effects

have suggested a tendency to hyperinflation in affected children with liver disease.3 Our patient suffers from severe deficiency due to ZPlowell genotype