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It usually occurs due to hormonal changes during pregnancy or due to use of oral contraceptives, or as a side effect of hormone replacement therapy

Its transport to mitochondria results in cell apoptosis via mitochondrial transmembrane potential (m) dissipation, cytochrome c release, and Bcl-2 - associated X protein (Bax) activation [93]

Emergence of Preexisting MET Y1230C Mutation as a Resistance Mechanism to Crizotinib in NSCLC with MET Exon 14 Skipping

FIGURE 7 4 CHAC enzymes beyond mammals Research on ChaC-like proteins has primarily focused on the mammalian homologs CHAC1 and CHAC2, with very few studies characterizing these enzymes in other organisms