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A recent study has shown that Yap is associated with the activation of ferroptosis, Yap can promote an iron environment in cancer cells through stimulating transcription of TEAF-based members of the Transferrin receptor (TFRC) and Acyl-CoA synthetase long chain family 4 (ACSL4) [129, 130]

[3] Additionally, glycine itself appears to have direct insulin-sensitizing properties: it stimulates glucagon-like peptide-1 (GLP-1) secretion from intestinal L-cells, activates hepatic GLP-1 receptors, and modulates bile acid composition in ways that favor improved glucose homeostasis

The challenges in targeting KRAS stem from its biological characteristics, such as a smooth surface lacking deep binding pockets and its high-affinity GTP-binding activity, which made the development of small-molecule inhibitors particularly difficult

Moreover, DHA-enriched diets alleviate NAFLD-associated characteristics and ferroptosis-induced hepatic injury in zebrafish