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Naltrexone modulates dopamine release following chronic, but not acute amphetamine administration: a translational study

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In REDEFINE 1 (overweight/obesity without T2D), CagriSema achieved mean weight reductions of 20.4-22.7% (vs 2.3-3.0% placebo) at 68 weeks, with 53.6% and 34.7% of patients achieving 20% and 25% weight loss, respectively

At concentrations that are high relative to the K m , the elimination rate is almost independent of concentrationa state of pseudo-zero order elimination